Luteolin is a natural flavonoid found in many plants.Luteoline powder has a variety of pharmacological activities, such as anti-inflammatory, anti-allergic, uric acid-lowering, anti-tumor, anti-bacterial, anti-viral, etc. It is mainly used for cough, expectorant, anti-inflammatory, uric acid-lowering, cardiovascular disease treatment, and treatment of amyotrophic lateral cord Sclerosis, SARS, hepatitis, etc.
It is currently believed that the anti-inflammatory activity of luteolin inhibits the production of nitric oxide (NO) and other inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and inhibits protein. Phosphorylation of tyrosine and nuclear transcription factor KB (NF-KB) mediated gene expression are involved.
Luteolin mainly inhibits the infiltration of cancer cells by altering the cell signaling pathway or inhibiting the activity of the cancer cells, and also inhibits the growth of tumor cells by blocking the cell cycle.
Luteolin inhibits immunoglobulin E (IgE)-mediated allergic transmitters produced by human mast cells, including histamine, leukotrienes, prostaglandin D2, and the release of mononuclear macrophage colony-stimulating factors. The role may be related to inhibition of Ca2+ influx and protein kinase C (PKC) translocation activation.
4. Anti-inflammatory demyelinating disease
Luteolin can dose-dependently protect oligodendrocytes against hydrogen peroxide-induced oxidative damage, strongly inhibit macrophage phagocytosis of myelin, and significantly reduce the production of reactive oxygen species.
Luteolin can reduce the degree of liver fibrosis, reduce the content of hydroxyproline (HYP), malondialdehyde (MDA) and type I procollagen mRNA in liver tissue, and inhibit hepatic stellate cells (HSC) in vitro. Proliferation and collagen synthesis. It can improve the histopathological changes of pulmonary fibrosis induced by bleomycin, reduce the lung weight index, significantly reduce the increase of MDA and HYP, and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in lung tissue. In vitro, it can inhibit the proliferation of human embryonic lung fibroblasts and promote their apoptosis.
This luteoline powder has anti-cancer, anti-bacterial, anti-inflammatory, expectorant, antispasmodic, anti-allergic and immune enhancement effects. The natural extract of this product has been used in clinical cough, expectorant and anti-inflammatory, and has good curative effect.
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