Solubility: Very soluble in chloroform,ethyacetate, benzeneand acetone
Artemisinin is the best drug for treating malaria. It is a sesquiterpene lactone drug with a peroxy group extracted from the traditional Chinese medicine Artemisia annua L.. It has high efficiency, quick effect, clearing heat, relieving heat, killing protozoa. It is characterized by low toxicity. At present, the combination therapy of artemisinin based on artemisinin for the treatment of malaria has reached more than 90%, and it has been widely used in the treatment of malaria in countries all over the world. It has a powerful and rapid killing effect on the red stage of the malaria parasite, and can quickly control clinical attacks and symptoms. At the same time, chicken coccidiosis, swine erythropoiesis, toxoplasmosis, yin deficiency fever, damp heat jaundice, vaginal malaria, falciparum malaria, cerebral malaria and anti-chloroquine malaria have outstanding effects.
1.Artemisinin is the most popular anti-malarial drug after acetaminophen, chloroquine and boquela. Especially for cerebral malaria and anti-chloroquine malaria, artemisinin has the characteristics of quick-acting and low-toxicity. It has been called by the World Health Organization. It is "the only effective malaria treatment drug in the world". Its anti-malarial mechanism is mainly due to the activation of artemisinin to produce free radicals during the treatment of malaria. The free radicals bind to the malaria protein and act on the membrane structure of the malaria parasite, causing the membrane, nuclear membrane and plasma membrane to be damaged. Upon destruction, the mitochondria swell and the inner and outer membranes fall off, thereby destroying the cell structure and function of the malaria parasite, and the chromatin in the nucleus is also affected. Artemisinin also significantly reduces the intake of isoleucine by the malaria parasite, thereby inhibiting the synthesis of protein in the worm.
2.The anti-tumor effect of artemisinin has gradually been discovered. Artemisinin can cause apoptosis of various cancer cells such as breast cancer cells, liver cancer cells, and cervical cancer cells, and has a significant inhibitory effect on the growth of cancer cells. The anti-tumor effect of artemisinin and its derivatives is mainly achieved by inducing apoptosis of cells. Dihydroartemisinin can inhibit the activation of hypoxia-induced related factors by increasing reactive oxygen species, thereby exerting selective cytotoxicity. Artemisia sphaeroides has a certain inhibitory effect on human colorectal cancer cells. It is found that artemisia sinensis has a dose-dependent effect on the proliferation inhibition and apoptosis promotion of human colorectal cancer cells. Mitochondria are amplifiers and receptors for apoptosis, which regulate the metabolic activities of cells, and the membrane potential of mitochondria induces apoptosis. Artemisinin acts on the cell membrane of leukemia cells, changes the permeability of the cell membrane, and increases the concentration of calcium ions in the cells, which not only activates calpain, but also causes it to swell and die, and promotes the release of apoptotic substances.
3.The antifungal action of artemisinin also makes artemisinin exhibit certain antibacterial activity. Studies have confirmed that artemisinin slag powder and decoction have strong antibacterial activity against Bacillus anthracis, Staphylococcus epidermidis, Kleococcus, and Diphtheria, for Mycobacterium tuberculosis, Pseudomonas aeruginosa, Staphylococcus aureus, Shigella also has a certain antibacterial effect.
This product is an efficient, fast-acting antimalarial drug. It acts on the intracellular phase of Plasmodium erythrocytes and is suitable for both P. vivax and Plasmodium falciparum, especially for the rescue of cerebral malaria. Its antipyretic time and malaria parasite turn time are shorter than chloroquine. For Plasmodium, which is resistant to chloroquine, it is also effective to use this product.
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