Dichroa Febrifuga Powder is extracted from the dried roots of Dichroa Febrifuga. It contains a variety of alkaloids, such as α-, β-, γ-dichroine, dichroidine, 4-quinazolone), dicnrin A, umbeli-ferone), and dictirin B. α-, β-, γ-dichroine have special effects on malaria. γ-dichroine has the strongest anti-malarial effect, and its effect is about 98-152 times that of quinine hydrochloride. β-dichroine is 89-122 times that of quinine, and the total alkali is about 26 times that of quinine.
1. Has an inhibitory effect on influenza A virus (PR8).
2. Alkaloids have a strong inhibitory effect on malaria parasites.
3. Has antihypertensive effect
4. Can stimulate the gastrointestinal tract and act on the vomiting center, causing vomiting.
Dichroa Febrifuga Powder
C 63.77%; H 6.35%; N 13.94%; O 15.93%
Shows high degree of antimalarial activity,antipyretic and emetic activities
Mp 139-140℃. Mp 154-156℃(dimorph.)
[α]25D +6 (c, 0.5 in CHCl3) (c, 0.5 in EtOH)
Partition Coefficient (Calculated):
Log P-0.33 (calc)
Dichroa Febrifuga Powder can used for content determination of/identification/pharmacology experiment, etc
COA of Febrifugine:
A.H-NMR:Comply with the structure
B.LC-MS:Comply with the structure
C.The IR spectrum of sample should be identical with that of reference standard;
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
meets the requirements.
Loss on drying
≤0.5%, determined on 1.0 g.
Unspecified impurities: for each impurity
99.0%~101.0% (anhydrous substance).
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